Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution.

@article{Takebayashi2004Sigma1RP,
  title={Sigma-1 receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: potential relation to lipid raft reconstitution.},
  author={Minoru Takebayashi and Teruo Hayashi and T. -P. Su},
  journal={Synapse},
  year={2004},
  volume={53 2},
  pages={90-103}
}
We previously demonstrated that overexpression of sigma-1 receptors (sigma-1R) potentiated neurite sprouting caused by nerve growth factor in PC12 cells (Takebayashi et al. 2002 J Pharmacol Exp Ther 202:1227-1237). In this study we examined if sigma-1R may be involved in the action of epidermal growth factor (EGF). EGF is conventionally recognized as a mitogenic factor that stimulates only the proliferation of various types of cells, including PC12 cells. We found here that in sigma-1 receptor… CONTINUE READING

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