Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor.

@article{Fujimoto2012Sigma1RC,
  title={Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor.},
  author={Michiko Fujimoto and Teruo Hayashi and Roman Urfer and Shiro Mita and T. -P. Su},
  journal={Synapse},
  year={2012},
  volume={66 7},
  pages={630-9}
}
The sigma-1 receptor (Sig-1R) is a novel endoplasmic reticulum (ER) molecular chaperone that regulates protein folding and degradation. The Sig-1R activation by agonists is known to improve memory, promote cell survival, and exert an antidepressant-like action in animals. Cutamesine (SA4503), a selective Sig-1R ligand, was shown to increase BDNF in the hippocampus of rats. How exactly the intracellular chaperone Sig-1R or associated ligand causes the increase of BDNF or any other neurotrophins… CONTINUE READING