Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.

@article{Vilner1995Sigma1AS,
  title={Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.},
  author={Bertold J. Vilner and Christy S. John and Wayne D. Bowen},
  journal={Cancer research},
  year={1995},
  volume={55 2},
  pages={408-13}
}
Thirteen tumor-derived cell lines of human and nonhuman origin and from various tissues were examined for the presence and density of sigma-1 and sigma-2 receptors. Sigma-1 receptors of a crude membrane fraction were labeled using [3H](+)-pentazocine, and sigma-2 receptors were labeled with [3H]1,3-di-o-tolylguanidine ([3H]DTG); in the presence or absence of dextrallorphan. [3H](+)-Pentazocine-binding sites were heterogeneous. In rodent cell lines (e.g., C6 glioma, N1E-115 neuroblastoma, and… CONTINUE READING
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