Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation

@inproceedings{Zhu2015Sigma1RA,
  title={Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation},
  author={Shanshan Zhu and Chenchen Wang and Yuan Ping Han and Chao Song and Xueming Hu and Yannan Liu},
  booktitle={Mediators of inflammation},
  year={2015}
}
Previous studies have demonstrated that sigma-1 receptor plays important roles in the induction phase of rodent neuropathic pain; however, whether it is involved in bone cancer pain (BCP) and the underlying mechanisms remain elusive. The aim of this study was to examine the potential role of the spinal sigma-1 receptor in the development of bone cancer pain. Walker 256 mammary gland carcinoma cells were implanted into the intramedullary space of the right tibia of Sprague-Dawley rats to induce… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Role of sigma-1 receptors in neurodegenerative diseases.

Journal of pharmacological sciences β€’ 2015
View 1 Excerpt

Novel approach to the role of NMDA receptors in traumatic brain injury.

CNS & neurological disorders drug targets β€’ 2014
View 1 Excerpt

Similar Papers

Loading similar papers…