Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.

@article{Gunten2005Siglec9TA,
  title={Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment.},
  author={Stephan von Gunten and Shida Yousefi and Michael Seitz and Stephan M. Jakob and Thomas Schaffner and Reinhard A. Seger and Jukka Takala and Peter Matthias Villiger and Hans-Uwe Simon},
  journal={Blood},
  year={2005},
  volume={106 4},
  pages={
          1423-31
        }
}
We report about new apoptotic and non-apoptotic death pathways in neutrophils that are initiated via the surface molecule sialic acid-binding immunoglobulin-like lectin (Siglec)-9. In normal neutrophils, Siglec-9 ligation induced apoptosis. Inflammatory neutrophils obtained from patients with acute septic shock or rheumatoid arthritis demonstrated increased Siglec-9, but normal Fas receptor-mediated cytotoxic responses when compared with normal blood neutrophils. The increased Siglec-9-mediated… CONTINUE READING

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