Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer.

@article{Aalto2011Siglec9IA,
  title={Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer.},
  author={Kristiina Aalto and Anu Autio and Elina A. Kiss and Kati Elima and Yvonne Nymalm and Tibor Z Veres and Fumiko Marttila-Ichihara and Heli Elovaara and Tiina Saanijoki and Paul R. Crocker and Mikael Maksimow and Eva Bligt and Tiina A Salminen and Marko Salmi and Anne Roivainen and Sirpa Jalkanen},
  journal={Blood},
  year={2011},
  volume={118 13},
  pages={
          3725-33
        }
}
Leukocyte migration to sites of inflammation is regulated by several endothelial adhesion molecules. Vascular adhesion protein-1 (VAP-1) is unique among the homing-associated molecules as it is both an enzyme that oxidizes primary amines and an adhesin. Although granulocytes can bind to endothelium via a VAP-1-dependent manner, the counter-receptor(s) on this leukocyte population is(are) not known. Here we used a phage display approach and identified Siglec-9 as a candidate ligand on… CONTINUE READING

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