Siglec-9 and SHP-1 Are Differentially Expressed in Neonatal and Adult Neutrophils

@article{Rashmi2009Siglec9AS,
  title={Siglec-9 and SHP-1 Are Differentially Expressed in Neonatal and Adult Neutrophils},
  author={R. Rashmi and B. Bode and N. Panesar and Sarah B King and James Rudloff and Melisa R Gartner and J. M. Koenig},
  journal={Pediatric Research},
  year={2009},
  volume={66},
  pages={266-271}
}
Neonatal PMN (polymorphonuclear neutrophils) exhibit altered inflammatory responsiveness and greater longevity compared with adult PMN; however, the involved mechanisms are incompletely defined. Receptors containing immunoreceptor tyrosine-based inhibitory motif (ITIM) domains promote apoptosis by activating inhibitory phosphatases, such as Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1), that block survival signals. Sialic acid-binding immunoglobulin-like lectin (Siglec)-9, an… Expand
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