Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.

@article{Angata2000Siglec7AS,
  title={Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.},
  author={Takashi Angata and Ajit Varki},
  journal={Glycobiology},
  year={2000},
  volume={10 4},
  pages={431-8}
}
The Siglecs are a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily. We report a molecule showing homology to the six first reported Siglecs, with the closest relationship to Siglec-3(CD33), Siglec-5, and Siglec-6(OBBP-1). The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig domain including amino acid residues known to be involved in sialic acid recognition by other Siglecs. The cytoplasmic domain has putative sites… CONTINUE READING

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