Sidestream tobacco smoke is a male germ cell mutagen.

  title={Sidestream tobacco smoke is a male germ cell mutagen.},
  author={Francesco Marchetti and Andrea Rowan-Carroll and Andrew L. Williams and Aris Polyzos and M Lynn Berndt-Weis and Carole Yauk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 31},
Active cigarette smoking increases oxidative damage, DNA adducts, DNA strand breaks, chromosomal aberrations, and heritable mutations in sperm. However, little is known regarding the effects of second-hand smoke on the male germ line. We show here that short-term exposure to mainstream tobacco smoke or sidestream tobacco smoke (STS), the main component of second-hand smoke, induces mutations at an expanded simple tandem repeat locus (Ms6-hm) in mouse sperm. We further show that the response to… CONTINUE READING
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