Side-specific effects of sodium on (Na,K)-ATPase. Studies with inside-out red cell membrane vesicles.

@article{Blostein1979SidespecificEO,
  title={Side-specific effects of sodium on (Na,K)-ATPase. Studies with inside-out red cell membrane vesicles.},
  author={Rhoda Blostein},
  journal={The Journal of biological chemistry},
  year={1979},
  volume={254 14},
  pages={6673-7}
}
Using inside-out vesicles of human red cell membranes, the side-specific effects of Na+ on phosphorylation of (Na,K)-ATPase have been studied using low concentrations of [gamma-32P]ATP (less than or equal to 0.1 microM). Phosphorylation is stimulated by Na+ at the cytoplasmic membrane surface (extravesicular Na+) alone and not by Na+ at the external surface (intravesicular Na+). At 37 degrees C, external Na+ (less than or equal to 10 mM) does, however, increase the steady state level… CONTINUE READING

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