Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.

@article{Kabashima2009SidePO,
  title={Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.},
  author={Ayano Kabashima and Hajime Higuchi and Hiromasa Takaishi and Yumi Matsuzaki and Sadafumi Suzuki and Motoko Izumiya and Hideko Iizuka and Gen Sakai and Shigenari Hozawa and Toshifumi Azuma and Toshifumi Hibi},
  journal={International journal of cancer},
  year={2009},
  volume={124 12},
  pages={2771-9}
}
We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epithelial phenotypic marker, and the cells formed tightly contacted cell cluster, which is a representative epithelial phenotypic appearance. When the SP cells were incubated in the… CONTINUE READING
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