Side population in MDA-MB-231 human breast cancer cells exhibits cancer stem cell-like properties without higher bone-metastatic potential.

An increasing body of evidence suggests that cancers contain a small subset of their own stem-like cells called cancer stem cells (CSCs), which play critical roles in the initiation, maintenance and relapse of tumors. However, the role of CSCs in cancer metastasis, especially in metastasis to bone, has not been extensively studied. Side population (SP) has… CONTINUE READING