Side effects of retroviral gene transfer into hematopoietic stem cells.

@article{Baum2003SideEO,
  title={Side effects of retroviral gene transfer into hematopoietic stem cells.},
  author={Christopher Baum and Jochen D{\"u}llmann and Zhixiong Li and Boris Fehse and Johann Meyer and David A. Williams and Christof von Kalle},
  journal={Blood},
  year={2003},
  volume={101 6},
  pages={
          2099-114
        }
}
Recent conceptual and technical improvements have resulted in clinically meaningful levels of gene transfer into repopulating hematopoietic stem cells. At the same time, evidence is accumulating that gene therapy may induce several kinds of unexpected side effects, based on preclinical and clinical data. To assess the therapeutic potential of genetic interventions in hematopoietic cells, it will be important to derive a classification of side effects, to obtain insights into their underlying… 

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Gene therapy for inherited disorders of haematopoietic cells.

  • C. KleinC. Baum
  • Biology, Medicine
    The hematology journal : the official journal of the European Haematology Association
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Improved retroviral or lentiviral techniques allow stable gene transfer in >10% of repopulating cells cultured in vitro, but severe impediments are still encountered with respect to achieving sufficient and long-lasting transgene expression levels and appropriate numbers of transgenic cells in vivo.

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...

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