Side effects of high-dose interferon therapy for chronic hepatitis C.

  title={Side effects of high-dose interferon therapy for chronic hepatitis C.},
  author={Takeshi Okanoue and Shigeru Sakamoto and Yoshito Itoh and Masahito Minami and Kohichiroh Yasui and Minoru Sakamoto and Kenichi Nishioji and Tatsuo Katagishi and Yasuo Nakagawa and Harue Tada and Yoshihide Sawa and Masashi Mizuno and Keizo Kagawa and Kei Kashima},
  journal={Journal of hepatology},
  volume={25 3},
BACKGROUND/AIMS Various side effects have been reported in patients treated with alpha interferon, but their incidence and prognosis remain unknown. METHODS Nine hundred and eighty-seven patients with chronic active hepatitis C received 6 to 10 MU of alpha interferon per day for 2 weeks and 3 times per week for 22 weeks. Autoantibodies, thyroid function tests, and fasting plasma glucose concentrations were evaluated prior to alpha interferon therapy. RESULTS Of the 987 patients, 310 were… CONTINUE READING
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