Side effects of brequinar and brequinar analogues, in combination with cyclosporine, in the rat.

@article{Pally1998SideEO,
  title={Side effects of brequinar and brequinar analogues, in combination with cyclosporine, in the rat.},
  author={Charles Pally and Donald Smith and Bruce B. Jaffee and Ronald L. Magolda and Hartmut Zehender and Birgit Dorobek and Peter Donatsch and Christos O. Papageorgiou and H. J. Schuurman},
  journal={Toxicology},
  year={1998},
  volume={127 1-3},
  pages={207-22}
}
Brequinar is an immunosuppressant with the potential to be combined with cyclosporine in synergistic combination therapy. The drug tends to accumulate when given daily per os, and pharmacokinetic interaction with cyclosporine appears to enhance toxicity. Analogues with similar immunosuppressive activity have been identified at Du Pont Merck Pharmaceutical Co., that do not accumulate upon daily oral dosing in rats, and hence could have an improved potential in combination treatment with… CONTINUE READING
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