Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs

@article{Ribeiro2013SideeffectsOA,
  title={Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs},
  author={Marta Maria Batista Ribeiro and S{\'o}nia S{\'a} Santos and David Cordeiro Sousa and Margarida Corte-Real Oliveira and Sara Matos Santos and Montserrat Bosch Heras and Eduard R. Bardaji and Isaura Let{\'i}cia Tavares and Miguel Castanho},
  journal={Amino Acids},
  year={2013},
  volume={45},
  pages={171-178}
}
The adverse side-effects associated with opioid administration restrain their use as analgesic drugs and call for new solutions to treat pain. Two kyotorphin derivatives, kyotorphin-amide (KTP–NH2) and ibuprofen–KTP–NH2 (IbKTP–NH2) are promising alternatives to opioids: they trigger analgesia via an indirect opioid mechanism and are highly effective in several pain models following systemic delivery. In vivo side-effects of KTP–NH2 and IbKTP–NH2 are, however, unknown and were evaluated in the… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Chemical conjugation

ER, I Tavares, MA Castanho
  • 2011