Side effects and placebo amplification.

  title={Side effects and placebo amplification.},
  author={Rachel Thomson},
  journal={The British journal of psychiatry : the journal of mental science},
  • Rachel Thomson
  • Published 1982 in
    The British journal of psychiatry : the journal…
A sample of placebo-controlled tricyclic antidepressant studies was examined retrospectively to determine whether there was any difference in the relative efficacy of the tricyclic when it was compared against an inert placebo as against an active (atropine) placebo with anticholinergic side effects. Fewer studies showed a significant difference between atropine placebo and drug than between inert placebo and drug. The possibilities that atropine has a specific antidepressant effect, or that… CONTINUE READING