Side effects and immunogenicity of murine lymphocyte-specific monoclonal antibodies in subhuman primates.

@article{Jonker1988SideEA,
  title={Side effects and immunogenicity of murine lymphocyte-specific monoclonal antibodies in subhuman primates.},
  author={Margreet Jonker and F J Nooij and G den Butter and R van Lambalgen and A J Fuccello},
  journal={Transplantation},
  year={1988},
  volume={45 4},
  pages={677-82}
}
The immediate side effects of lymphocyte-specific monoclonal antibody treatment of nearly 150 monkeys is documented in this study. Immediate side effects were only seen with antibodies specific for CD3 and CD8. These side effects are most likely related to stimulation of T cells to produce lymphokines (CD3) and/or to the rapid cell clearance (CD3 and CD8). No immediate effects were observed when CD4 or major histocompatibility complex class II-specific antibodies were injected. These antibodies… CONTINUE READING