Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents.

@article{Idowu1995SidechainHI,
  title={Side-chain hydroxylation in the metabolism of 8-aminoquinoline antiparasitic agents.},
  author={Olutosin R. Idowu and James O. Peggins and Thomas G. Brewer},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1995},
  volume={23 1},
  pages={18-27}
}
Primaquine, 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline, is an antimalarial 8-aminoquinoline derivative. Although it has been in use since 1952, its metabolism has not been clearly defined. This is due to the instability of the expected aminophenol metabolites and their amphoteric nature, which makes their isolation difficult. Recent studies on the metabolism of WR 238605, a new primaquine analog, has shown that these problems may be solved by extracting the metabolites in the presence of… CONTINUE READING