Side chain homologation of alanyl peptide nucleic acids: pairing selectivity and stacking.

@article{Diederichsen2005SideCH,
  title={Side chain homologation of alanyl peptide nucleic acids: pairing selectivity and stacking.},
  author={Ulf Diederichsen and Daniel Weicherding and Nicola Diezemann},
  journal={Organic & biomolecular chemistry},
  year={2005},
  volume={3 6},
  pages={1058-66}
}
Alanyl peptide nucleic acids (alanyl-PNAs) are oligomers based on a regular peptide backbone with alternating configuration of the amino acids. All side chains are modified by covalently linked nucleobases. Alanyl-PNAs form very rigid, well defined, and linear double strands based on hydrogen bonding of complementary strands, stacking, and solvation. Side chain homology was examined by comparing a methylene linker (alanyl-PNA) with an ethylene linker (homoalanyl-PNA), a trimethylene linker… CONTINUE READING