Side Chain Anchoring of Tryptophan to Solid Supports Using a Dihydropyranyl Handle: Synthesis of Brevianamide F

@article{TorresGarca2011SideCA,
  title={Side Chain Anchoring of Tryptophan to Solid Supports Using a Dihydropyranyl Handle: Synthesis of Brevianamide F},
  author={Carolina Torres-Garc{\'i}a and Mireia D{\'i}az and Daniel Blasi and Immaculada Farr{\`a}s and Irene Mart{\'i}n Fern{\'a}ndez and Xavier Ariza and Jaume Farr{\`a}s and Paul Lloyd-Williams and Miriam Royo and Ernesto Nicol{\'a}s},
  journal={International Journal of Peptide Research and Therapeutics},
  year={2011},
  volume={18},
  pages={7-19}
}
The multifunctional character of tryptophan has made it a target for the development of new molecules with therapeutic applications. In this sense the design of alternative solid phase routes would allow the widening of synthetic possibilities to access these molecules through conventional or combinatorial strategies. The present work describes a new strategy for side-chain anchoring of tryptophan to dihydropyranyl-functionalized polystyrene resins and its application to the synthesis of the… CONTINUE READING
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