Sickness behavior of rats with abdominal sepsis can be improved by antibiotic and G-CSF prophylaxis in clinic modeling randomized trials

@article{Bauhofer2004SicknessBO,
  title={Sickness behavior of rats with abdominal sepsis can be improved by antibiotic and G-CSF prophylaxis in clinic modeling randomized trials},
  author={Artur Bauhofer and Rainer K. W. Schwarting and Mario K{\"o}ster and Antonin Schmitt and Wilfried Lorenz and Cornelius Rainer Pawlak},
  journal={Inflammation Research},
  year={2004},
  volume={53},
  pages={697-705}
}
Background and aim: In clinical sepsis research nearly all immune-modulators have demonstrated no benefit in regard to the 28-day mortality rate. Other endpoints such as quality of life have become more attractive, but clinically relevant animal models analyzing an equivalent to quality of life by measurement of sickness behavior are extremely rare. The concept of clinic modeling randomized trials was used in an animal trial to model clinical complexity and conditions of a randomized clinical… CONTINUE READING

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