Sickle-cell trait: novel clinical significance.

  title={Sickle-cell trait: novel clinical significance.},
  author={Nigel S Key and Vimal K Derebail},
  journal={Hematology. American Society of Hematology. Education Program},
There is a long-standing controversy in the literature as to whether sickle-cell trait (SCT) should be viewed as a benign carrier state or as an intermediate disease phenotype. Because SCT is routinely detected by neonatal screening for sickle-cell disease, it becomes imperative that consensus on this issue be achieved in order to provide the best medical advice to affected individuals. The issue of selective screening in the post-neonatal period was thrust into the limelight recently by the… CONTINUE READING

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