Sickle cell disease among tribes of Andhra Pradesh and Orissa, India.

@article{Babu2002SickleCD,
  title={Sickle cell disease among tribes of Andhra Pradesh and Orissa, India.},
  author={Bontha Veerraju Babu and B. Leela and Yadlapalli S Kusuma},
  journal={Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur},
  year={2002},
  volume={60 2},
  pages={
          169-74
        }
}
Sickle cell disease is observed to occur in significantly high frequencies amongst the tribes of India. It has surged to the fore as an important public health problem among tribal groups, which needs serious attention. This paper presents the distribution of this abnormal genetic problem among scheduled tribes of India, in general and among those of Andhra Pradesh and Orissa states, in detail. Though the prevalence of sickle cell trait is high, the sickle cell disease cases are found to be… 
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7 Citations

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Beyond the screening: The need for health systems intervention for prevention and management of sickle cell disease among tribal population of India.
TLDR
The burden of SCD among the tribes in two Indian states of Andhra Pradesh and Telangana is demonstrated, as a case and the need for public health intervention and health systems strengthening in the country to prevent and manage SCD is highlighted.
NEGATIVE EPISTASIS BETWEEN α+ THALASSAEMIA AND SICKLE CELL TRAIT CAN EXPLAIN INTERPOPULATION VARIATION IN SOUTH ASIA
TLDR
It is shown that very high levels of α+ thalassaemia combined with varying levels of malaria selection can explain why sickle cell has penetrated certain South Asian populations but not others.
Genetic counselling in tribals in India
TLDR
Genetic counselling in tribals unlike general population residing in cities and near villages is a difficult task due to their lower literacy and poor socio-economic status and therefore the need for setting up of permanent centres in the tribal areas in India.
Sickle Cell Anemia—Molecular Diagnosis and Prenatal Counseling: SGPGI Experience
TLDR
The knowledge of the relationship between genotype and phenotype, effect of the modifier genes has an important role in genetic counseling and for planning individualized treatment for sickle cell anemia.
Abnormal haemoglobins: detection & characterization
TLDR
The recommended strategy is to use a combination of cation-exchange high performance chromatography, capillary electrophoresis (CE) and when possible isoelectric focusing (IEF) and the necessity to characterize the abnormalities using at least two different methods.
Clinical events in a large prospective cohort of children with sickle cell disease in Nagpur, India: evidence against a milder clinical phenotype in India
TLDR
The objective of this large single‐center study was to examine the rate of complications to define the phenotype of SCD in India.
Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India
TLDR
This work studied the feasibility of delivering comprehensive SCD care in a community‐based network for remote, economically, and socially disadvantaged tribes in Gudalur, India.