616 Citations
Pulmonary hypertension in adolescents with sickle cell disease
- Medicine, Biology
- 2016
With vaso-occlusion being the major complication in sickle cell disease and affecting many tissues and organs like the lungs, pulmonary hypertension has become a major risk factor in patients, especially in children.
Sickle cell disease: Clinical presentation and management of a global health challenge.
- MedicineBlood reviews
- 2019
Liver damage and sickle cell disease: genotype relationship
- MedicineAnnals of Hematology
- 2020
Male sex, SCA genotype, lower HbF, frequent transfusions, increased GGT values, and abnormal liver ultrasound and stiffness were identified as potentially early markers of sickle hepatopathy.
Complement in sickle cell disease and targeted therapy: I know one thing, that I know nothing.
- Medicine, BiologyBlood reviews
- 2021
Interventions for chronic kidney disease in people with sickle cell disease.
- MedicineThe Cochrane database of systematic reviews
- 2017
The effectiveness of any intervention in preventing or reducing kidney complications or chronic kidney disease in people with SCD, including red blood cell transfusions, hydroxyurea and angiotensin-converting enzyme inhibitor (ACEI), either alone or in combination with each other is assessed.
Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
- MedicineThe Cochrane database of systematic reviews
- 2020
It is very uncertain whether long-term transfusions: reduce the risk of transient ischaemic attacks, Peto odds ratio, or increase quality of life across different outcomes according to GRADE methodology.
Magnesium for treating sickle cell disease.
- MedicineThe Cochrane database of systematic reviews
- 2019
The studies show that oral magnesium therapy may prevent sickle red blood cell dehydration and prevent recurrent painful episodes, and there is a need to access evidence for the impact of oral and intravenous magnesium effect on frequency of pain, length of hospital stay and quality of life.
Pulmonary complications in adult patients with sickle cell disease
- Medicine
- 2018
The present review comprises the following pulmonary complications of SCD: i) acute chest syndrome, ii) venous thromboembolus, iii) asthma, iv) respiratory dysfunction, v) respiratory disorders during sleeping, vi) pulmonary hypertension.
Current challenges in the management of patients with sickle cell disease – A report of the Italian experience
- MedicineOrphanet Journal of Rare Diseases
- 2019
The historical experience of the network of hemoglobinopathy centers and their approach to SCD in Italy is described, a country where hemoglobinopathies have a high prevalence and where SCD, associated with different genotypes including ß-thalassemia, is present in the native population.
References
SHOWING 1-10 OF 151 REFERENCES
Advances in clinical research in sickle cell disease
- MedicineBritish journal of haematology
- 2008
Clinical research reviewed includes pulmonary hypertension, which is emerging as a particularly deadly scourge of adults with any haemolytic anaemia, and newer insights into older, more established complications and treatments, such as red cell transfusions, the need for and use of iron chelation and avascular necrosis.
Hematopoietic cell transplantation for thalassemia and sickle cell disease: past, present and future
- MedicineBone Marrow Transplantation
- 2008
The pediatric experience of HCT for hemoglobinopathies is illustrated and how these results affect future therapeutic decisions in children who inherit these disorders is discussed.
Sickle cell disease in Africa: burden and research priorities
- MedicineAnnals of tropical medicine and parasitology
- 2007
This review details the epidemiological and clinical background of SCD, with an emphasis on Africa, before identifying the research priorities that will provide the necessary evidence base for improving the management of African patients.
A CASE OF SICKLE CELL ANEMIA WITH NECROPSY
- Medicine
- 1924
Sickle cell anemia is a new disease, in the sense that it is just coming into general attention. It appears to be a familial disease or status peculiar to the negro race. Chief of its characteristics…
Cerebrovascular disease associated with sickle cell pulmonary hypertension
- Medicine, BiologyAmerican journal of hematology
- 2006
Six patients with obliterative central nervous system vasculopathy who also have pulmonary hypertension and high hemolytic rate are reported, suggesting that cerebrovascular disease and pulmonary hypertension in sickle cell disease share common mechanisms, in particular, reduced nitric oxide bioactivity associated with particularly high‐grade hemolysis.
Sickle cell disease and the kidney.
- MedicineSeminars in nephrology
- 2003
Kidney transplantation offers a major advantage to survival, and should be coupled with efforts toward prevention of recurrent disease, especially in patients with a history of sickle cell disease.
Two different forms of homozygous sickle cell disease occur in Saudi Arabia
- MedicineBritish journal of haematology
- 1991
The disease in the Eastern province has many mild features consistent with the higher HbF levels and more frequent alpha thalassaemia but bone pathology (painful crises, avascular necrosis of the femoral head, osteomyelitis) remains common and the disease inThe West is more severe consistent withThe Benin haplotype suggesting an African origin.
Hemolysis-associated priapism in sickle cell disease.
- MedicineBlood
- 2005
Case subjects with priapism had significantly lower levels of hemoglobin; higher levels of lactate dehydrogenase, bilirubin, and aspartate aminotransferase; and higher reticulocyte, white blood cell, and platelet counts, suggesting an association of priapist with increased hemolysis.
Cerebrovascular accidents in sickle cell disease: rates and risk factors.
- MedicineBlood
- 1998
The highest rates of prevalence of CVA and incidence were in sickle cell anemia (SS) patients, but CVA occurred in all common genotypes, and the incidence of infarctive CVA was lowest in SS patients 20 to 29 years of age and higher in children and older patients.