Sickle cell disease (SCD), iNKT cells, and regadenoson infusion.

  title={Sickle cell disease (SCD), iNKT cells, and regadenoson infusion.},
  author={David G. Nathan and Joshua J Field and Gene Wei-Chin Lin and Donna S Neuberg and Elaine M Majerus and Onyinye C Onyekwere and Jeffrey M Keefer and Maureen M Okam and Ainsley Ross and Joel M Linden},
  journal={Transactions of the American Clinical and Climatological Association},
  pages={312-7; discussion 317-8}
A humanized murine sickle cell-disease (SCD) model (NY1DD) has been used to study ischemia/reperfusion injury (IRI) in sickle cell anemia, and iNKT cells (a very small subset of murine and human T cells) have been found to instigate such injury in this model. Furthermore, levels of activated iNKT cells are generally elevated in the circulation of patients… CONTINUE READING