Sickle cell disease: old discoveries, new concepts, and future promise.

@article{Frenette2007SickleCD,
  title={Sickle cell disease: old discoveries, new concepts, and future promise.},
  author={Paul S Frenette and George F. Atweh},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 4},
  pages={850-8}
}
The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances. 

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