Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes.

@article{Shet2003SickleBC,
  title={Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes.},
  author={Arun S. Shet and Omer Aras and Kalpna Gupta and Mathew J Hass and Douglas J Rausch and Nabil R Saba and Louann Koopmeiners and Nigel S Key and Robert P. Hebbel},
  journal={Blood},
  year={2003},
  volume={102 7},
  pages={2678-83}
}
Blood microparticles (MPs) in sickle cell disease (SCD) are reportedly derived only from erythrocytes and platelets. Yet in SCD, endothelial cells and monocytes are activated and abnormally express tissue factor (TF). Thus, sickle blood might contain TF-positive MPs derived from these cells. With the use of flow cytometry to enumerate and characterize MPs, we found total MPs to be elevated in crisis (P =.0001) and steady state (P =.02) in subjects with sickle cell disease versus control… CONTINUE READING