Sickle Cell Anemia: Reexamining the First "Molecular Disease"

@article{Feldman1997SickleCA,
  title={Sickle Cell Anemia: Reexamining the First "Molecular Disease"},
  author={Simon D. Feldman and S D Tauber},
  journal={Bulletin of the History of Medicine},
  year={1997},
  volume={71},
  pages={623 - 650}
}
Pauling (L.) demontra, grâce au developpement de la biologie moleculaire, que l'anemie est due a l'existence d'une aberration physicochimique de la molecule d'hemoglobine 
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Between black and miscegenated population groups: sickle cell anemia and sickle cell trait in Brazil in the 1930s and 1940s.
TLDR
The article explores the ambivalences stemming from associations between sickle cell anemia and the 'black race' during this period of miscegenation in Brazil.
The emerging understanding of sickle cell disease
TLDR
The first indisputable case of sickle cell disease in the literature was described in a dental student studying in Chicago between 1904 and 1907 and it was Dr Lemuel Diggs of Memphis who first clearly distinguished symptomatic cases called Sickle cell anaemia from the latent asymptomatic cases which were termed the sicklecell trait.
Entre negros e miscigenados: a anemia e o traço falciforme no Brasil nas décadas de 1930 e 1940
TLDR
The article explores the ambivalences stemming from associations between sickle cell anemia and the ‘black race’ during this period of miscegenation in Brazil.
The first 'molecular disease': a story of Linus Pauling, the intellectual patron.
Signs, markers, profiles, and signatures: clinical haematology meets the new genetics (1980–2000)
TLDR
This article analyzes the development of the new genetics in clinical haematology since the mid‐1980s, focusing on two recent instantiations of the molecular biology platform: RT‐PCR and DNA microarrays.
Linus Pauling's "molecular diseases": between history and memory.
  • B. Strasser
  • Biology
    American journal of medical genetics
  • 2002
TLDR
The history of Pauling's sickle cell anemia and its subsequent integration in different collective memories, up to the present day are explored.
Racial mixture, blood and nation in medical publications on sickle cell disease in 1950s Brazil.
  • J. M. Cavalcanti
  • Political Science
    History and philosophy of the life sciences
  • 2019
TLDR
Although race as a biological concept gradually gave way to other genetic expressions, in Brazilian medical papers on sickle cell disease, race continued to influence the interpretation of the disease, along with the persistence of concepts of heredity through blood mixture.
From Screening to Clinical Research: The Cure of Leukemia and the Early Development of the Cooperative Oncology Groups, 1955-1966
TLDR
This paper examines part of the process of the emergence of biomedicine by focusing on the development of clinical cancer trials in the United States in the years 1955-66, a period during which the clinical trials program run by the National Cancer Institute became autonomous from the Institute's screening program for anticancer compounds.
Defining Genetic Disease
The concept of genetic disease refers to the idea that one or more genes are the cause of disease. Under this definition, problems arise when it comes to the use of the term “cause”. Moreover, genes…
Contribution à l'histoire de la recherche médicale : autour des travaux de Jean Bernard et de ses collaborateurs sur la leucémie aiguë, 1940-1970
Ce travail rend compte des recherches sur la leucemie aigue menees par Jean Bernard et ses collaborateurs de 1940 a 1970 et les replace dans les transformations globales de la recherche medicale au…
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References

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TLDR
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TLDR
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TLDR
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