Sick and tired: does sleep have a vital role in the immune system?

@article{Bryant2004SickAT,
  title={Sick and tired: does sleep have a vital role in the immune system?},
  author={P. Bryant and J. Trinder and N. Curtis},
  journal={Nature Reviews Immunology},
  year={2004},
  volume={4},
  pages={457-467}
}
It is a common belief that we are more susceptible to infections when deprived of sleep. Consistent with this, there is increasing evidence that sleep deprivation has detrimental effects on the immune response, indicating that sleep should be considered a vital part of the immune system and that there is a reciprocal relationship between sleep and immunity. This relationship is important because, over recent decades, there has been a documented decrease in the mean duration and quality of sleep… Expand

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References

SHOWING 1-10 OF 149 REFERENCES
Neural-immune interactions in the regulation of sleep.
  • M. Opp, L. Toth
  • Medicine
  • Frontiers in bioscience : a journal and virtual library
  • 2003
TLDR
This work reviews relevant literature documenting that sleep patterns do indeed change during states of infectious disease, discusses potential mediators of these alterations in behavior, and addresses the issue of whether sleep or sleep loss impacts the ability of the host to mount an appropriate immune response. Expand
Mediators of Inflammation and Their Interaction with Sleep
TLDR
In humans, activation of the primary host defense system leads to increased or decreased NREM sleep quality, depending on the degree of early immune activation, including TNF‐α, its soluble receptors, and IL‐6, present in the periphery and the CNS. Expand
Sleep disturbance in early HIV infection.
TLDR
While reasons for sleep structure distortion remain unknown, new data suggests that irregular levels of peptides may be involved and this could lead to therapies that restore sleep and improve quality of life. Expand
Humoral Links between Sleep and the Immune System
TLDR
It is reached the tentative conclusion that the sleep‐promoting actions of IL‐1 and GHRH are mediated via anterior hypothalamic neurons that are receptive to these substances, and it seems likely that TNF‐α and CRH also influence these neurons. Expand
Sustained sleep deprivation impairs host defense.
  • C. Everson
  • Biology, Medicine
  • The American journal of physiology
  • 1993
TLDR
The results suggest that the life-threatening condition of prolonged sleep deprivation is a breakdown of host defense against indigenous and pathogenic microorganisms. Expand
Sleep disruption in the intensive care unit
TLDR
Although several questions remain unanswered, including the impact of sleep disruption on the clinical outcome of patients in the ICU, there is a growing interest in developing new strategies to improve sleep quality. Expand
Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness
TLDR
The common cold can have detrimental effects on sleep and psychomotor performance in symptomatic individuals during the initial active phase of the illness. Expand
Dose-dependent effects of endotoxin on human sleep.
TLDR
Whereas it is well established that the endocrine and thermoregulatory systems are very sensitive to endotoxin, this study shows that human sleep-wake behavior is even more sensitive to activation of host defense mechanisms. Expand
The relationship of interleukin‐1 and immune functions to sleep in humans.
TLDR
Dramatic increase in IL‐1 activity along with changes in other immune functions occurred during sleep and were related to onset of slow wave sleep. Expand
Effects of sleep deprivation and other stressors on the immune and inflammatory responses of influenza-infected mice.
TLDR
The data indicate that sleep deprivation and altered light cycles do not markedly influence selected host defense responses to influenza infection under the conditions tested. Expand
...
1
2
3
4
5
...