Sichuan pepper extracts block the PAK1/cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice.

@article{Hirokawa2006SichuanPE,
  title={Sichuan pepper extracts block the PAK1/cyclin D1 pathway and the growth of NF1-deficient cancer xenograft in mice.},
  author={Yumiko Hirokawa and Thao V Nheu and Kirsten A. Grimm and V Mautner and Satoko Maeda and Minoru Yoshida and Kanki Komiyama and Hiroshi Maruta},
  journal={Cancer biology & therapy},
  year={2006},
  volume={5 3},
  pages={305-9}
}
There is increasing evidence that more than 70% of cancers including pancreatic, breast and prostate cancers as well as neurofibromatosis (NF) are highly addicted to abnormal activation of the Ser/Thr kinase PAK1 for their growth. So far FK228 is the most potent among the HDAC (histone deacetylase) inhibitors that block the activation of both PAK1 and another kinase AKT, downstream of PI-3 kinase. However, FK228 is still in clinical trials (phase 2) for a variety of cancers (but not for NF as… CONTINUE READING

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