Sibling recurrence and the genetic epidemiology of autism.

  title={Sibling recurrence and the genetic epidemiology of autism.},
  author={John N Constantino and Yi Zhang and Thomas W. Frazier and Anna M Abbacchi and Paul A. Law},
  journal={The American journal of psychiatry},
  volume={167 11},
OBJECTIVE Although the symptoms of autism exhibit quantitative distributions in nature, estimates of recurrence risk in families have never previously considered or incorporated quantitative characterization of the autistic phenotype among siblings. METHOD The authors report the results of quantitative characterization of 2,920 children from 1,235 families participating in a national volunteer register, with at least one child clinically affected by an autism spectrum disorder and at least… CONTINUE READING

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