Sibling pair linkage and association studies between bone mineral density and the insulin-like growth factor I gene locus.

@article{Takcs1999SiblingPL,
  title={Sibling pair linkage and association studies between bone mineral density and the insulin-like growth factor I gene locus.},
  author={Istv{\'a}n Tak{\'a}cs and Daniel L. Koller and Munro Peacock and Joe C. Christian and Siu L. Hui and P. Michael Conneally and Conrad Johnston and Tatiana Foroud and Michael J. Econs},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 12},
  pages={
          4467-71
        }
}
A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. BMD is a complex trait that presumably is influenced by multiple genes. Insulin-like growth factor I (IGF-I) is an attractive candidate gene for osteoporosis susceptibility, because IGF-I has marked effects on bone cells and has been implicated in the pathogenesis of osteoporosis. The IGF-I gene contains a microsatellite repeat polymorphism approximately 1 kb upstream… CONTINUE READING

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