Sibling cases of Addison's disease caused by DAX-1 gene mutations.

  title={Sibling cases of Addison's disease caused by DAX-1 gene mutations.},
  author={Yoshihiro Sekiguchi and Yoshihito Hara and Hiroshi Matsuoka and Yoshiki Hayashi and Noriyuki Katsumata and Yukio Hirata},
  journal={Internal medicine},
  volume={46 1},
We report two sibling cases of Addison's disease without any evidence of sexual precocity, adrenal hyperplasia, or autoimmune disease. The diagnosis of primary adrenocortical insufficiency was made at the age of 5 in the younger brother and at the age of 18 in the elder brother. The younger brother had been inactive during infancy and had diffuse skin pigmentation without abnormal external genitalia, while the elder brother had been healthy until the age of 17 when he noticed skin pigmentation… CONTINUE READING
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