Siamois cooperates with TGFbeta signals to induce the complete function of the Spemann-Mangold organizer.

@article{Engleka2001SiamoisCW,
  title={Siamois cooperates with TGFbeta signals to induce the complete function of the Spemann-Mangold organizer.},
  author={Mark J Engleka and Daniel S. Kessler},
  journal={The International journal of developmental biology},
  year={2001},
  volume={45 1},
  pages={
          241-50
        }
}
In Xenopus, the Spemann-Mangold organizer induces and patterns the body axis. Siamois, a Wnt-responsive transcriptional activator, functions to establish and maintain the Spemann-Mangold organizer by regulating organizer gene transcription. While expression of Siamois in marginal blastomeres induces an axis consisting of both head and trunk structures, we show that expression of Siamois in animal blastomeres induces an axis that lacks head structures. Consistent with the absence of head… CONTINUE READING