Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosa.

@article{Dohi1990SialylpentaosylceramideDW,
  title={Sialylpentaosylceramide detected with anti-GM2 monoclonal antibody. Structural characterization and complementary expression with GM2 in gastric cancer and normal gastric mucosa.},
  author={Taeko Dohi and Satoshi Ohta and Nobuo Hanai and Kozo Yamaguchi and Motohiko Oshima},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 14},
  pages={7880-5}
}
The ganglioside fraction of human gastric mucosa was analyzed with a newly established anti-GM2 monoclonal antibody KM531. Using this antibody, accumulation of GM2 was observed in all of four cases of gastric carcinoma. In all ganglioside fractions extracted from normal gastric mucosa obtained from eight cases of peptic ulcer GM2 itself was not detected, but three kinds of glycolipid showing slower mobility than GM2 on thin-layer plates were detected by immunostaining with KM531. These… CONTINUE READING