Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells.

Abstract

β-Galactoside α2,6-sialyltransferase (ST6Gal-I) has been shown to catalyze α2,6 sialylation of N-glycan, an action that is highly correlated with colon cancer progression and metastasis. We have recently demonstrated that ST6Gal-I-induced α2,6 sialylation is critical for adhesion and migration of colon cancer cells. Increase of α2,6 sialylation also… (More)
DOI: 10.1016/j.bcp.2012.01.007

Cite this paper

@article{Park2012SialylationOE, title={Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells.}, author={Jung-Jin Park and Jae Youn Yi and Yeung Bae Jin and Yoon-Jin Lee and Jae-Seon Lee and Yun-Sil Lee and Young-Gyu Ko and Minyoung Lee}, journal={Biochemical pharmacology}, year={2012}, volume={83 7}, pages={849-57} }