Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting.

@article{Cohen2010SialylationO3,
  title={Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting.},
  author={Merav Cohen and Moshe Elkabets and Michal Perlmutter and Angel Porgador and Elena Voronov and Ron N. Apte and Rachel G. Lichtenstein},
  journal={Journal of immunology},
  year={2010},
  volume={185 10},
  pages={5869-78}
}
Sialylation of tumor cells is involved in various aspects of their malignancy (proliferation, motility, invasion, and metastasis); however, its effect on the process of immunoediting that affects tumor cell immunogenicity has not been studied. We have shown that in mice with impaired immunoediting, such as in IL-1α(-/-) and IFNγ(-/-) mice, 3-methylcholanthrene-induced fibrosarcoma cells are immunogenic and concomitantly bear low levels of surface sialylation, whereas tumor cells derived from… CONTINUE READING
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