Sialylation of 3-Methylcholanthrene–Induced Fibrosarcoma Determines Antitumor Immune Responses during Immunoediting

@article{Cohen2010SialylationO3,
  title={Sialylation of 3-Methylcholanthrene–Induced Fibrosarcoma Determines Antitumor Immune Responses during Immunoediting},
  author={Merav Cohen and Moshe Elkabets and Michal Perlmutter and Angel Porgador and Elena Voronov and Ron N. Apte and Rachel G. Lichtenstein},
  journal={The Journal of Immunology},
  year={2010},
  volume={185},
  pages={5869 - 5878}
}
Sialylation of tumor cells is involved in various aspects of their malignancy (proliferation, motility, invasion, and metastasis); however, its effect on the process of immunoediting that affects tumor cell immunogenicity has not been studied. We have shown that in mice with impaired immunoediting, such as in IL-1α−/− and IFNγ−/− mice, 3-methylcholanthrene–induced fibrosarcoma cells are immunogenic and concomitantly bear low levels of surface sialylation, whereas tumor cells derived from wild… 
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TLDR
It is hypothesized that tumor-associated O-glycans not only support tumor growth, but also actively contribute to immune evasion, thereby focusing on truncated O- Glycans present on epithelial tumors and mucins.
Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy
TLDR
The role of tumor-associated glycans in anti-tumor immunity is discussed, with an emphasis on the potential of γδ T cells to target the tumor glycocode.
The immunomodulating roles of glycoproteins in epithelial ovarian cancer.
TLDR
This review focuses first on the immune environment in ovarian cancer, and the mechanisms of activation and inhibition that immune cells undergo in order to either attack or ignore a target cell.
Sweet escape: sialic acids in tumor immune evasion.
TLDR
Current studies showing that tumor-derived sialic acids disable major killing mechanisms of effector immune cells, trigger production of immune suppressive cytokines and dampen activation of antigen-presenting cells and subsequent induction of anti-tumor immune responses are reviewed.
Sialoglycans and Siglecs Can Shape the Tumor Immune Microenvironment.
TLDR
It is posited that sialoglycans and Siglecs present as potential glyco-immune 'checkpoints' for cancer immunotherapy.
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