Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

  title={Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition},
  author={Mark R. Charbonneau and David H. O’Donnell and Laura V. Blanton and Sarah M. Totten and Jasmine C. C. Davis and Michael J Barratt and Jiye Cheng and Janaki L. Guruge and Michael Talcott and James R. Bain and Michael J. Muehlbauer and Olga Ilkayeva and Chao Wu and Tedd Struckmeyer and Daniela Barile and Charles Mangani and Josh M Jorgensen and Yue-mei Fan and Kenneth M Maleta and Kathryn G Dewey and Per Ashorn and Christopher B. Newgard and Carlito B. Lebrilla and David A. Mills and Jeffrey I. Gordon},
Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month… CONTINUE READING
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