Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis

@inproceedings{Bartsch2018SialylatedAI,
  title={Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis},
  author={Yannic C. Bartsch and Johann Rahm{\"o}ller and Maria M. M. Mertes and Susanne Eiglmeier and Felix Lorenz and Alexander D. Stoehr and Dominique Braumann and Alexandra Lorenz and Andr{\'e} Winkler and Gina-Maria Lilienthal and Janina Petry and Juliane Hobusch and Moritz Steinhaus and Constanze Hess and Vivien Holecska and Carolin T. Schoen and Carolin M. Oefner and Alexei Leliavski and V{\'e}ronique Blanchard and Marc Ehlers},
  booktitle={Front. Immunol.},
  year={2018}
}
Pro- and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; G0) IgG Abs in the serum of rheumatoid arthritis and systemic lupus erythematosus (SLE) patients reflects severity of the diseases. In contrast, sialylated IgG Abs are responsible for anti-inflammatory effects of the intravenous immunoglobulin (pooled human serum IgG from healthy donors), administered in high doses (2 g… CONTINUE READING