Sialyl-lewis-X, Gleason grade and stage in non-metastatic human prostate cancer

  title={Sialyl-lewis-X, Gleason grade and stage in non-metastatic human prostate cancer},
  author={Halliday A. Idikio},
  journal={Glycoconjugate Journal},
  • H. Idikio
  • Published 1 November 1997
  • Medicine
  • Glycoconjugate Journal
Early stage prostate cancers are now commonly encountered because of widespread use of screening tools. Increased cancer cell proliferation, and expression of sialyl Lewis could be important as predictors of clinical behaviour and survival in addition to histologic grade. In this study, the expression of sialyl-Lewisx (sLex) was determined by immunohistochemical methods in 38 routinely processed prostate biopsies and transurethral resections preceeding radical prostatectomies for organ confined… 
Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance.
PURPOSE To evaluate the prognostic relevance of CEACAM1 and sialyl Lewis X expression in adenocarcinomas of the lung. PATIENTS AND METHODS Paraffin wax sections of 93 patients with adenocarcinomas
Glycophenotype of bone metastases of prostatic carcinomas
The findings of this study showed that bone metastasis is associated with two very different glycan phenotypes, the first in the primary tumours and the second in the bone metastases, and showed that prostatic metastatic tumours apart fromBone metastases have glycophenotype that, in some metastased sites, are similar to those of the primary sites while in others they areSimilar to that of the Bone metastases.
Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis
It was showed that sLeX overexpression is significantly related to lymphatic invasion, venous invasion, T stage, N stage, M stage, tumor stage, recurrence, and overall survival in cancer patients, it plays an important role in cancer prognosis.
The Impact of ABO Blood Group on Biochemical Recurrence after Radical Prostatectomy
Pre-op PSA, Gleason score, surgical margin and extra-prostatic extension were significantly associated with biochemical recurrence-free survival, while the log-rank test showed no significant associations between blood group and PSA failure at the univariate level and Multivariate.
Glycophenotype of prostatic carcinomas
The observations of this study suggest that the gylcophenotype of transformed prostatic cells was modified, and o-glycans seems to play an important role in the glycosylation patterns found in prostate carcinoma cells.
Expression o f C EACAM1 i n A denocarcinoma o f t he L ung: A F actor o f I ndependent P rognostic S ignificance
expression of CEACAM1 was an independent prognostic factor in the patient population and can be used to stratify patients with adenocarcinomas of the lung into low-risk and high-risk groups, which can lead to new therapeutic strategies in the future.
Glycophenotype of prostatic carcinomas.
The observations of this study suggest that the gylcophenotype of transformed prostatic cells was modified, which showed a moderate increase in, and changing patterns of, fucosylation and galacto-glycosylation, increased branching of side chains and sharp rise in 2 deoxy, 2 acetamido galactosylations and masking process by sialylation.
Definition of molecular determinants of prostate cancer cell bone extravasation.
How metastatic prostate cancer cells breach BMEC monolayers in a step-wise fashion under physiologic hemodynamic flow is described and the requirement for E-selectin ligands, α1,3 fucosyltransferases, β1 and αVβ3 integrins, and Rac/Rap1 GTPases in mediating prostate cancer cell homing and entry into bone is unified.
Gene transfer of α1,3‐fucosyltransferase increases tumor growth of the PC‐3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells
The results suggest that prostate cancer cells gain aggressiveness through adhesive interaction with prostatic stromal cells by a novel mechanism involving sialyl Lewis X.
Tumor and Stem Cell Biology De fi nition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells


Sialyl-Lewis(x) and related carbohydrate antigens in the prostate.
For prostate, Le(y) and SLe(x) are the only blood group-related antigens known to be minimal or absent in benign secretory epithelial cells that are more highly expressed in malignant tissue.
Blood vessel invasion and expression of sialyl lewisx and proliferating cell nuclear antigen in stage I non‐small cell lung cancer. Relation to postoperative recurrence
Background. Recurrence in Stage I non‐small cell lung cancer was examined with respect to vascular invasion and the immunohistochemical expression of sialyldimeric Lewisx (SLX) and proliferating cell
Oligosaccharide signals: from plant defense to parasite offense.
  • C. Ryan
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1994
The article in this issue describes the first example in which a defined oligosaccharide, lacto-N-fucopentaose III (LNFPIII), derived from a surface antigen of the eggs of a parasite, plays a signaling role in the interaction of parasite with its animal host, thereby regulating the immune responses of the -host.
Human Pathol 26: 735—39
  • Hakamori S-i
  • 1995