Sialyl-lewis-X, Gleason grade and stage in non-metastatic human prostate cancer

@article{Idikio2004SialyllewisXGG,
  title={Sialyl-lewis-X, Gleason grade and stage in non-metastatic human prostate cancer},
  author={Halliday A. Idikio},
  journal={Glycoconjugate Journal},
  year={2004},
  volume={14},
  pages={875-877}
}
  • H. Idikio
  • Published 1 November 1997
  • Medicine
  • Glycoconjugate Journal
Early stage prostate cancers are now commonly encountered because of widespread use of screening tools. Increased cancer cell proliferation, and expression of sialyl Lewis could be important as predictors of clinical behaviour and survival in addition to histologic grade. In this study, the expression of sialyl-Lewisx (sLex) was determined by immunohistochemical methods in 38 routinely processed prostate biopsies and transurethral resections preceeding radical prostatectomies for organ confined… 
Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance.
PURPOSE To evaluate the prognostic relevance of CEACAM1 and sialyl Lewis X expression in adenocarcinomas of the lung. PATIENTS AND METHODS Paraffin wax sections of 93 patients with adenocarcinomas
Glycophenotype of bone metastases of prostatic carcinomas
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Glycophenotype of prostatic carcinomas.
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The observations of this study suggest that the gylcophenotype of transformed prostatic cells was modified, which showed a moderate increase in, and changing patterns of, fucosylation and galacto-glycosylation, increased branching of side chains and sharp rise in 2 deoxy, 2 acetamido galactosylations and masking process by sialylation.
Definition of molecular determinants of prostate cancer cell bone extravasation.
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How metastatic prostate cancer cells breach BMEC monolayers in a step-wise fashion under physiologic hemodynamic flow is described and the requirement for E-selectin ligands, α1,3 fucosyltransferases, β1 and αVβ3 integrins, and Rac/Rap1 GTPases in mediating prostate cancer cell homing and entry into bone is unified.
Gene transfer of α1,3‐fucosyltransferase increases tumor growth of the PC‐3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells
TLDR
The results suggest that prostate cancer cells gain aggressiveness through adhesive interaction with prostatic stromal cells by a novel mechanism involving sialyl Lewis X.
Tumor and Stem Cell Biology De fi nition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation
Advanced prostate cancer commonly metastasizes to bone, but transit of malignant cells across the bone marrow endothelium (BMEC) remains a poorly understood step in metastasis. Prostate cancer cells
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Background. Recurrence in Stage I non‐small cell lung cancer was examined with respect to vascular invasion and the immunohistochemical expression of sialyldimeric Lewisx (SLX) and proliferating cell
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