Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model

@article{Julien2009SialylTnVI,
  title={Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model},
  author={Sylvain Julien and Gianfranco Picco and Robert D E Sewell and A-S Vercoutter-Edouart and Maja Tarp and David W. Miles and Henrik Clausen and Joyce Taylor-Papadimitriou and Joy M. Burchell},
  journal={British Journal of Cancer},
  year={2009},
  volume={100},
  pages={1746 - 1754}
}
Changes in the composition of glycans added to glycoproteins and glycolipids are characteristic of the change to malignancy. Sialyl-Tn (STn) is expressed by 25–30% of breast carcinomas but its expression on normal tissue is highly restricted. Sialyl-Tn is an O-linked disaccharide that can be carried on various glycoproteins. One such glycoprotein MUC1 is expressed by the vast majority of breast carcinomas. Both STn and MUC1 have been considered as targets for immunotherapy of breast cancer… CONTINUE READING

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