Sialyl-Tn antigen expression and O-linked GalNAc-Thr synthesis by Trypanosoma cruzi.

@article{Freire2003SialylTnAE,
  title={Sialyl-Tn antigen expression and O-linked GalNAc-Thr synthesis by Trypanosoma cruzi.},
  author={Teresa Freire and Carlos Robello and Silvia Soul{\'e} and Fernando Rog{\'e}rio Lara Ferreira and Eduardo Osinaga},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={312 4},
  pages={1309-16}
}
Most Trypanosoma cruzi O-glycans are linked to Thr/Ser residues via N-acetylglucosamine. We report that the mucin-type carcinoma-associated sialyl-Tn antigen (NeuAc-GalNAc-O-Ser/Thr) is expressed by T. cruzi. A specific MAb allowed us to localize the antigen on the surface of epimastigotes and to identify reactive components in parasite lysates (32, 60, and 94kDa). In addition, ppGalNAc-T activity was characterized in epimastigotes, and direct evidence was obtained for the in vitro… CONTINUE READING

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