Sialogogue-related radioprotection of salivary gland function: the degranulation concept revisited.

@article{Coppes1997SialogoguerelatedRO,
  title={Sialogogue-related radioprotection of salivary gland function: the degranulation concept revisited.},
  author={Rob P Coppes and L. J. W. Zeilstra and A Vissink and Antonius W. T. Konings},
  journal={Radiation research},
  year={1997},
  volume={148 3},
  pages={240-7}
}
To investigate whether secretory granules play a role in the radiosensitivity of the salivary glands of rats, parotid acinar cells, submandibular acinar cells and/or submandibular granular convoluted tubule (GCT) cells were degranulated prior to irradiation. Degranulation of GCT cells was obtained by pretreatment with phenylephrine (5 mg/kg, t = -60 min) and methacholine (3.75 mg/kg, t = -120 min). Degranulation of acinar cells was attained by pretreatment with isoproterenol (5 mg/kg, t = -90… CONTINUE READING