Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis

@inproceedings{Samanta2012SialoglycosylationOR,
  title={Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis},
  author={Sajal Samanta and Angana Ghoshal and Kaushik Bhattacharya and Bibhuti Saha and Peter Walden and Chitra Mandal},
  booktitle={PloS one},
  year={2012}
}
Visceral leishmaniasis (VL) caused by the intracellular parasite Leishmania donovani accounts for an estimated 12 million cases of human infection. It is almost always associated with anemia, which severely complicates the disease course. However, the pathological processes leading to anemia in VL have thus far not been adequately characterized to date. In studying the glycosylation patterns of peripheral blood cells we found that the red blood cells (RBC) of VL patients (RBC(VL)) express eight… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

O-acetylation of sialic acids- their detection, biological significance and alteration in diseases- a Review

D Sinha, M Chatterjee, C Mandal
Trends in Glycosci. Glycotechnol • 2000
View 3 Excerpts
Highly Influenced

Calpain (Ca(2+)-dependent thiol protease) in erythrocytes of young and old individuals.

Proceedings of the National Academy of Sciences of the United States of America • 1994
View 3 Excerpts
Highly Influenced

Control of the leishmaniasis ( Geneva )

A Ghoshal, S Mukhopadhyay, B Saha, C Mandal
Tech Rep Ser • 2010

Similar Papers

Loading similar papers…