Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a.

@article{Wang2009SialidaseOI,
  title={Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a.},
  author={Jianfeng Wang and Gusheng Wu and Taeko Miyagi and Z Lu and Robert W. Ledeen},
  journal={Journal of neurochemistry},
  year={2009},
  volume={111 2},
  pages={547-54}
}
Previous reports indicated the presence of both gangliosides and sialidase in the nuclear envelope (NE) of primary neurons and the NG108-15 neural cell line. GM1, one of the major gangliosides of this membrane, was shown to be tightly associated with a sodium-calcium exchanger in the inner membrane of the NE and to potentiate exchanger activity. GD1a was the other major ganglioside detected in the NE and, like GM1, occurs in both inner and outer membranes. A subsequent report indicated the… CONTINUE READING

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