Sialidase and sialoglycoproteases can modulate virulence in Porphyromonas gingivalis.

@article{Aruni2011SialidaseAS,
  title={Sialidase and sialoglycoproteases can modulate virulence in Porphyromonas gingivalis.},
  author={Wilson Aruni and Elaine A Vanterpool and Devon O. Osbourne and F. Sutar Roy and Arun S. Muthiah and Yuetan Dou and H M Fletcher},
  journal={Infection and immunity},
  year={2011},
  volume={79 7},
  pages={2779-91}
}
The Porphyromonas gingivalis recombinant VimA can interact with the gingipains and several other proteins, including a sialidase. Sialylation can be involved in protein maturation; however, its role in virulence regulation in P. gingivalis is unknown. The three sialidase-related proteins in P. gingivalis showed the characteristic sialidase Asp signature motif (SXDXGXTW) and other unique domains. To evaluate the roles of the associated genes, randomly chosen P. gingivalis isogenic mutants… CONTINUE READING
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