Sialic acid recognition by Vibrio cholerae neuraminidase.

  title={Sialic acid recognition by Vibrio cholerae neuraminidase.},
  author={Ibrahim Moustafa and Helen Connaris and Margaret Taylor and Viateslav Zaitsev and Jennifer C. Wilson and Milton J Kiefel and Mark von Itzstein and Garry L. Taylor},
  journal={The Journal of biological chemistry},
  volume={279 39},
Vibrio cholerae neuraminidase (VCNA) plays a significant role in the pathogenesis of cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor for cholera toxin. We previously showed that the structure of VCNA is composed of a central beta-propeller catalytic domain flanked by two lectin-like domains; however the nature of the carbohydrates recognized by these lectin domains has remained unknown. We present here structures of the enzyme in complex with two… CONTINUE READING
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