Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses

@article{Nicholls2007SialicAR,
  title={Sialic acid receptor detection in the human respiratory tract: evidence for widespread distribution of potential binding sites for human and avian influenza viruses},
  author={John Malcolm Nicholls and Anthony J. Bourne and Honglin Chen and Yi Guan and Joseph Sriyal Malik Peiris},
  journal={Respiratory Research},
  year={2007},
  volume={8},
  pages={73 - 73}
}
BACKGROUND Influenza virus binds to cell receptors via sialic acid (SA) linked glycoproteins. They recognize SA on host cells through their haemagglutinins (H). The distribution of SA on cell surfaces is one determinant of host tropism and understanding its expression on human cells and tissues is important for understanding influenza pathogenesis. The objective of this study therefore was to optimize the detection of alpha2,3-linked and alpha2,6-linked SA by lectin histochemistry by… CONTINUE READING
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